Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage | Zendy

Ebina Yasuhiko | Zendy; Shimada Shigeki | Zendy; Deguchi Masashi | Zendy; Maesawa Yoko | Zendy; Iijima Norifumi | Zendy; Yamada Hideto | Zendy

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Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage

Author(s) -

Ebina Yasuhiko,

Shimada Shigeki,

Deguchi Masashi,

Maesawa Yoko,

Iijima Norifumi,

Yamada Hideto

Publication year - 2016

Publication title -

american journal of reproductive immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.071

H-Index - 97

eISSN - 1600-0897

pISSN - 1046-7408

DOI - 10.1111/aji.12546

Subject(s) - decidua , cytotoxic t cell , foxp3 , flow cytometry , fetus , recurrent miscarriage , karyotype , biology , andrology , miscarriage , immunology , medicine , immune system , microbiology and biotechnology , pregnancy , chromosome , placenta , genetics , gene , in vitro

Problem The aim of this prospective study was to evaluate phenotypic differences of helper T (Th), cytotoxic T (Tc), and regulatory T (Treg) cells in the deciduae of missed miscarriage with a normal chromosome karyotype of a fetus ( MN ) and missed miscarriage with an abnormal chromosome karyotype of a fetus ( MA ). Methods of study The decidua of 19 MN and 28 MA was obtained. Additionally, the decidua of 15 induced abortion ( IA ) and the endometrium of 19 non‐pregnant women ( EM ) were obtained. IFN ‐γ + , IL ‐17 + , CD 25 high Foxp3 + cells in CD 4 + (Th) cells, and IFN ‐γ + cells in CD 8 + (Tc) cells were evaluated by flow cytometry. Results The percentages of IFN ‐γ + Tc and CD 4 + CD 25 high Foxp3 + (Treg) cells in MN were significantly increased as compared with MA and IA . The percentage of IFN ‐γ + Th in MN was increased as compared with IA . Conclusion Activation of IFN ‐γ + Tc and Treg cells in the decidua might be associated with the pathophysiology underlying MN .

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