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Metabolic and immunologic aspects of fetoplacental insufficiency
Author(s) -
Bekmukhambetov Yerbol,
Mamyrbayev Arstan,
Dzharkenov Timur,
Kravtsova Natalia,
Utesheva Zhanar,
Tusupkaliev Akylbek,
Ryzhkova Svetlana,
Darzhanova Klara,
Bekzhanova Maral
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12544
Subject(s) - placental insufficiency , immune system , placenta , lymphocyte , fetus , immunology , biology , antigen , pregnancy , medicine , endocrinology , andrology , genetics
Problem The chronic placental insufficiency is the most common cause of intrauterine hypoxia, retardation of fetal growth, and other threatening conditions. Immune disturbances may occur in the system “mother–placenta–fetus.” Method of study Biochemical blood indicators were studied on an automated biochemical analyzer. Pattern of lymphocyte subpopulations was detected by direct membrane immunofluorescence. Results Study revealed imbalance of immune parameters, caused by placental insufficiency (increase natural killers ( CD 16 + , CD 56 + ), B lymphocytes ( CD 19 + CD 3 − ), T and B lymphocytes with HLA ‐ DR + antigen, and early activation of immune cells (by CD 25 + ), as well as disorders in apoptotic mechanisms (by CD 95 + )). Conclusion Placental insufficiency leads to abnormalities of the immune system in pregnant, parturient women and maternity patients which were evaluated by localization of activation markers CD 25 + CD 95 + on the CD 3 + , CD 4 + , CD 8 + , CD 16 + , CD 56 + lymphocytes. This is reflected in the change of lymphocyte functions in newborns.