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Association of interleukin‐10 gene promoter polymorphisms with recurrent miscarriage: a meta‐analysis
Author(s) -
Su Duo,
Zhang Yeye,
Wang Qingqin,
Wang Jing,
Jiao Baoquan,
Wang Gang,
Wu Xiaohua
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12531
Subject(s) - odds ratio , confidence interval , recurrent miscarriage , meta analysis , haplotype , miscarriage , medicine , case control study , gene , oncology , polymorphism (computer science) , gene polymorphism , biology , genetics , bioinformatics , allele , pregnancy
Problem The association between IL ‐10 gene promoter polymorphisms and the risk of recurrent miscarriages ( RM ) remains controversial. The present meta‐analysis was performed to derive a precise estimate of the relationship. Method of study We searched the PubMed and EMBASE for studies related to the association between the IL ‐10 gene polymorphism and the risk of RM . Summary odds ratio ( OR ) with 95% confidence interval ( CI ) was estimated to assess the associations. Results Thirteen studies, including 2047 RM cases and 2055 control samples, were identified. The results showed a significant association between rs1800896, rs1800871 and RM risk (for rs1800896: GA + GG vs AA : OR =1.20, 95% CI =1.04–1.39, P =.02; for rs1800871: CT + TT vs CC : OR =1.64, 95% CI =1.13–2.36, P =.009). No evidence of association was noted between rs1800872 haplotype and RM risk. Conclusion IL ‐10 gene promoter polymorphisms, rs1800896 and rs1800871, play a potential role in increasing the risk of RM .