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Metabolic syndrome is associated with increased seminal inflammatory cytokines and reproductive dysfunction in a case‐controlled male cohort
Author(s) -
Leisegang Kristian,
Bouic Patrick J. D.,
Henkel Ralf R.
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12529
Subject(s) - metabolic syndrome , sperm , semen , male infertility , inflammation , fertility , semen analysis , infertility , andrology , medicine , biology , physiology , endocrinology , population , pregnancy , obesity , environmental health , genetics
Problem The impact of metabolic syndrome (MetS) associated systemic inflammation on the male reproductive tract requires further investigation. Method of study A cross‐sectional case‐controlled study design consisting of a control group (n=32) and a MetS (n=42) group was used. Variables include MetS diagnostic criterion, serum C‐Reactive Protein ( CRP ), routine semen analysis, spermatozoa mitochondrial membrane potential ( MMP ) and DNA fragmentation ( DF ), as well as TNF ‐α, IL ‐1β, IL 6 and IL 8 concentrations in serum and semen. Results Serum and seminal levels of TNF ‐α, IL ‐1β, IL 6 and IL 8 were all significantly increased in the MetS group. Ejaculation volume, sperm concentration, total sperm count, progressive and total motility and vitality were significantly decreased and sperm with abnormal MMP and DF were increased in the MetS group. Conclusion The results suggest that MetS is associated with decreased fertility parameters in males, as well as local reproductive tract inflammation, in the absence of leukocytospermia.