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Serum concentrations of soluble B7‐H4 in early pregnancy are elevated in women with preterm premature rupture of fetal membranes
Author(s) -
Mach Pawel,
Köninger Angela,
Wicherek Lukasz,
Kimmig Rainer,
KasimirBauer Sabine,
Birdir Cahit,
Schmidt Börge,
Gellhaus Alexandra
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12527
Subject(s) - medicine , pregnancy , premature rupture of membranes , gestation , fetus , obstetrics , amniotic fluid , complication , gestational age , gastroenterology , gynecology , genetics , biology
Problem To determine the association between maternal soluble B7‐H4 (sB7‐H4) and the preterm premature rupture of the amniotic membranes (pPROM), the blood serum concentration levels of sB7‐H4 were studied. Method of study Maternal serum levels of sB7‐H4 were determined with enzyme‐linked immunosorbent assay (ELISA) in patients between 11 and 13 weeks’ gestation who later on in the pregnancy developed pPROM (n=21), premature rupture of the amniotic membranes at term (n=18), and in control group (n=27). Results The highest serum levels of sB7‐H4 were found in patients who developed pPROM. An OR of 1.39 (95%‐CI: 1.17–1.77; P =.002) per ng/mL sB7‐H4 indicated an increased risk for developing pPROM, with some predictive ability to discriminate between pPROM cases and controls (AUC=.81). Conclusion Increased serum levels of sB7‐H4 in early pregnancy in pPROM cases may indicate the dynamics of the immune response at the feto‐maternal interface and, thus, may serve as a predictive marker for this pregnancy complication.