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Incidence of Sperm Surface Autoantibodies and Relationship with Routine Semen Parameters and Sperm Kinematics
Author(s) -
Verón Gustavo Luis,
Molina Rosa Isabel,
Tissera Andrea Daniela,
Estofan Gustavo Martín,
MarínBriggiler Clara Isabel,
VazquezLevin Mónica Hebe
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12519
Subject(s) - sperm , semen , semen analysis , sperm motility , andrology , medicine , incidence (geometry) , infertility , biology , pregnancy , physics , optics , genetics
Problem Antisperm antibodies ( ASA ) are associated with male subfertility. However, results on sperm surface autoantibodies are controversial, the relationship between ASA and semen parameters ( WHO , 2010) is unknown, and data on ASA and sperm kinematics are scarce. Method of study A retrospective study carried out in men undergoing routine semen analysis ( WHO 2010), ASA evaluation (direct Sperm MAR ™ (IgG) test), and computer‐assisted sperm analysis ( CASA ). Results A 2.6% and a 5.9% incidence of ASA ‐positive cases were found (cut‐off 50% and 10%, respectively; n = 7492). ASA ‐positive samples had lower ( P < 0.0001) sperm concentration, count, motility, and hypo‐osmotic swelling ( HOS ) test score. HOS results did not correlate with sperm vitality in normozoospermic samples with high ASA levels. In unselected samples, ASA ‐positive samples (cut‐off 50%) showed decreased sperm kinematics ( VSL , VAP , LIN , ALH , STR , BCF , WOB ), but in normozoospermic samples, ASA ‐positive and ASA ‐negative subgroups had similar CASA results. Conclusions ASA evaluation is highly relevant in full semen assessment.