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Fyn Plays a Pivotal Role in Fetomaternal Tolerance Through Regulation of Th17 Cells
Author(s) -
Liu Qian,
Tian Fuju,
Xie Qingzhen,
Zhang Jun,
Liu Liu,
Yang Jing
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12498
Subject(s) - fyn , immune system , medicine , immunology , abortion , regulator , proinflammatory cytokine , immune tolerance , endocrinology , pregnancy , biology , inflammation , tyrosine kinase , genetics , receptor , gene
Problem Spontaneous abortion is a poorly understood phenomenon, although fetomaternal intolerance is known to play an important role in its pathogenesis. The tyrosine‐specific phosphotransferase Fyn has been reported as a significant regulator in immune response. However, its role in fetomaternal immune tolerance and contribution to spontaneous abortion remains unclear. Methods of study Fyn expression was evaluated at the fetomaternal interface of normal pregnant and abortion‐prone mice, as well as in decidual tissue obtained from normal human pregnancies and idiopathic miscarriages. A Fyn inhibitor was administrated into the LPS ‐induced abortion mice to investigate the variation of embryo resorption and local immunity. Results Fyn expression fluctuated with the progress of normal pregnancy and was elevated in abortion‐prone mice and patients with recurrent spontaneous abortion. The Fyn inhibitor reversed LPS ‐induced embryo absorption and aberrant inflammatory status including redundant expression of IRF 4 and increased proportion of Th17 cells. Conclusion Fyn is confirmed as a negative regulator in fetomaternal immune tolerance, through promoting Th17 cell expansion and proinflammatory factors expression.