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Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra‐Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High‐Sensitive PCR System
Author(s) -
Yoneda Satoshi,
Shiozaki Arihiro,
Yoneda Noriko,
Ito Mika,
Shima Tomoko,
Fukuda Kaori,
Ueno Tomohiro,
Niimi Hideki,
Kitajima Isao,
Kigawa Mika,
Saito Shigeru
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12484
Subject(s) - gestation , antibiotics , amniotic fluid , antibiotic therapy , preterm labor , medicine , obstetrics , pregnancy , biology , physiology , microbiology and biotechnology , fetus , genetics
Objectives To examine the efficacy of the use of antibiotics in preterm labor ( PTL ) with intact membranes, after evaluating intra‐amniotic microbes by our rapid and bacteria‐free polymerase chain reaction ( PCR ) system. Materials and methods One hundred and four PTL patients before 32 weeks of gestation were recruited. Until 2012, antibiotics were empirically prescribed based on the clinical severity of PTL . Intra‐amniotic microbes in stored samples were evaluated later by our newly established PCR system, and the efficacy of the use of antibiotics in PTL was evaluated. Results In the amniotic fluid ( AF ) microbe‐negative patients ( n = 67), antibiotic therapy significantly shortened the gestation period ( P < 0.0001), whereas in the microbe‐positive patients ( n = 37), appropriate antibiotic therapy (proper antibiotic selection against identified AF microbes) was significantly associated with an increase in gestation period ( P < 0.0001). Conclusion Appropriate antibiotic therapy in PTL with intact membranes prolonged the gestation period.