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Association of Interleukin‐10‐1082A/G Polymorphism with Idiopathic Recurrent Miscarriage: A Systematic Review and Meta‐Analysis
Author(s) -
Peng Zheng,
Lv Xiaolan,
Sun Yifan,
Dai Shengming
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12467
Subject(s) - meta analysis , cochrane library , medicine , genotype , miscarriage , allele , polymorphism (computer science) , web of science , gastroenterology , bioinformatics , pregnancy , genetics , biology , gene
Problem This systematic review and meta‐analysis aimed to synthesize and assess the correlation between the interleukin‐10 ( IL ‐10)‐1082A/G polymorphism and idiopathic recurrent miscarriage ( IRM ) using relevant studies. Method of study Five electronic databases (Cochrane Library of Systematic Reviews, PubMed, EMBASE , Web of Science, and Google Scholar) were comprehensively searched up to August 2015. Data were extracted independently by two members of our team. Results The meta‐analysis of 13 eligible studies suggested a recessive effect of the G allele (‐1082A/G polymorphism) for IRM risk. Conclusions The pooled evidence demonstrated that the GG genotype increased IRM risk.