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Immunocontraception for Animals: Current Status and Future Perspective
Author(s) -
Naz Rajesh K.,
Saver Ashley E.
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12431
Subject(s) - culling , fertility , sterilization (economics) , biology , population control , overpopulation , physiology , domestic animal , population , microbiology and biotechnology , gynecology , family planning , medicine , environmental health , zoology , business , research methodology , herd , finance , exchange rate , foreign exchange market
An alternative to surgical sterilization for fertility control of animals (wild, zoo, farm, and domestic) is needed to prevent problems related to overpopulation, including culling and relocation. A PubMed and Google Scholar database search was conducted using the keywords ‘contraceptive vaccine animals,’ ‘immunocontraception animals,’ ‘non‐surgical sterilization animals,’ ‘ PZP vaccine,’ and ‘Gn RH vaccine.’ The searches from 1972 to 2015 yielded over 1500 publications. These articles were read, and 375 were selected for detailed analysis. Articles referenced in these publications were also thoroughly examined. PZP and Gn RH contraceptive vaccines ( CV s) have been extensively investigated for fertility control of wild, zoo, farm, and domestic animal populations. Both vaccines have shown tremendous success with PZP vaccines taking the lead. Novel technologies and targets are being developed to improve existing vaccines and generate second‐generation CV s. Single‐shot vaccines, which can be delivered remotely, will greatly advance the field of immunocontraception for animal use with potential human application.