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Reduced Circulating Concentration of Brain‐derived Neurotrophic Factor is Associated with Peri‐ and Post‐implantation Failure following In Vitro Fertilization–Embryo Transfer
Author(s) -
Ramer Ilana,
Kruczek Alexis,
Doulaveris Georgios,
Orfanelli Theofano,
Shulman Brittney,
Witkin Steven S.,
Spandorfer Steven D.
Publication year - 2016
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12430
Subject(s) - in vitro fertilisation , brain derived neurotrophic factor , embryo transfer , pregnancy , medicine , abortion , neurotrophic factors , embryo , neurotrophin , andrology , human fertilization , assisted reproductive technology , obstetrics , gynecology , infertility , biology , anatomy , receptor , genetics , microbiology and biotechnology
Problem We evaluated associations between brain‐derived neurotrophic factor ( BDNF ) and neurotrophin‐4 ( NT 4) and pregnancy outcome in women undergoing in vitro fertilization–embryo transfer ( IVF ‐ ET ). Method of study Sera obtained on days 24 and 28 of an IVF cycle from women with a live birth, spontaneous abortion, biochemical pregnancy, not pregnant, or an ectopic pregnancy were retrospectively analyzed for BDNF and NT 4 by ELISA . Results Median BDNF levels were higher in women with a live birth compared to women with an ectopic pregnancy ( P < 0.0001), spontaneous abortion ( P < 0.0001), or a biochemical pregnancy ( P = 0.0004), but not in women who did not become pregnant. NT 4 was detected in <25% of sera and did not differ by outcome. There was no association between BDNF level and oocyte or pre‐transfer embryo parameters. Conclusion Decreased circulating BDNF early in an IVF cycle is associated with adverse peri‐ and/or post‐implantation events and subsequent pregnancy failure.