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Viral Infection‐Induced Differential Expression of Lnc RNA s Associated with Collagen in Mouse Placentas and Amniotic Sacs
Author(s) -
Pan Jing,
Mor Gil,
Ju Weina,
Zhong Julia,
Luo Xiucui,
Aldo Paulomi Bole,
Zhong Mei,
Yu Yanhong,
Jenkins Edmund C.,
Brown William T.,
Zhong Nanbert
Publication year - 2015
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12406
Subject(s) - biology , microbiology and biotechnology , transcription (linguistics) , messenger rna , placenta , rna , long non coding rna , gene expression , immunology , virology , gene , pregnancy , fetus , genetics , philosophy , linguistics
Problem We have previously determined that long non‐coding RNA s (lnc RNA s) are differentially expressed in preterm premature rupture of membranes ( PPROM ) and hypothesized that the collagenolysis ubiquitin–proteasome system may be activated by infection and inflammation. However, direct evidence of the involvement of lnc RNA s in transcriptional and posttranscriptional regulation of the infection‐triggered alteration of collagen is lacking. Method of study A previously developed mouse model with MHV 68 viral infection was assessed to determine whether viral infection may induce differential expression of lnc RNA s in mouse placentas and amniotic sacs. Results Differential expression of lnc RNA s that are associated with collagen was found in HMV 68 viral‐infected, compared to non‐infected, mouse placentas and amniotic sacs. Differential expression of messenger RNA s ( mRNA s) of collagen was also documented. Conclusions Our data demonstrate, for the first time, that viral infection may induce the differential expression of lnc RNA s that are associated with collagen. Based on this finding, we propose that lnc RNA may have involved in regulating of infection‐induced collagen transcription.