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Expression of CCL 22 and Infiltration by Regulatory T Cells are Increased in the Decidua of Human Miscarriage Placentas
Author(s) -
Freier Christoph P.,
Kuhn Christina,
Rapp Moritz,
Endres Stefan,
Mayr Doris,
Friese Klaus,
Anz David,
Jeschke Udo
Publication year - 2015
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12399
Subject(s) - ccl22 , decidua , stromal cell , foxp3 , biology , infiltration (hvac) , andrology , decidual cells , chemokine , miscarriage , placenta , immunology , pregnancy , cancer research , fetus , medicine , immune system , cxcl10 , genetics , physics , thermodynamics
Problem Regulatory T cells (Treg) are a T‐cell subpopulation with suppressive capacities, specifically attracted by CCL 22. We aimed to investigate whether CCL 22 is expressed in human placentas and whether its presence, together with Treg infiltration, is associated with miscarriage conditions. Method of study Paraffin samples were stained for CCL 22 and for the Treg‐specific transcription factor FoxP3. Expression levels were evaluated in a semi‐quantitative manner. Double immunofluorescence was used for the identification of CCL 22‐producing cells. Results In all placentas, trophoblasts expressed CCL 22. Interestingly, expression in the decidua was only observed in miscarriage conditions. Maternal stromal cells expressed CCL 22. Correlation with a higher presence of Treg in the decidua of abortive tissues was observed. Conclusion Our results demonstrate that CCL 22 is expressed in human placenta. Decidual expression was only observed in miscarriage conditions and correlates with Treg infiltration. Thus, CCL 22 plays a role in human pregnancy and may occur as a negative feedback response to pro‐inflammatory events during miscarriage conditions.