Accurate Prediction of the Stage of Histological Chorioamnionitis before Delivery by Amniotic Fluid IL‐8 Level

Objective To estimate the stage of histological chorioamnionitis (h‐ CAM ) antenatally using clinical data. Materials and methods Four hundred and twenty‐eight singleton mothers were recruited. Clinical data including the levels of white blood cell count ( WBC ), C‐reactive protein ( CRP ), amniotic fluid interleukin‐8 ( AF ‐ IL ‐8) at Cesarean section, and maternal body temperature ( MBT ) were collected. Results Histological chorioamnionitis was present in 45.3% of the cases. Poor neonatal prognosis was highest (59.1%) in cases with h‐ CAM stage III . AF ‐ IL ‐8 (odds ratio: 8.5, 95% CI : 5.1‐14.8, P  <   0.0001) and MBT (odds ratio: 2.3, 95% CI : 1.13–4.1, P  =   0.0192) were independent risk factors for h‐ CAM . The cutoff value of AF ‐ IL ‐8 for predicting each stage of h‐ CAM (stage I or higher, stage II or higher, and stage III ) were ≥9.9 ng/mL, ≥17.3 ng/mL, and ≥55.9 ng/mL, respectively. Conclusion The stage of h‐ CAM was able to be predicted accurately by the level of AF ‐ IL ‐8 before delivery.