Premium
NLRP1 L155H Polymorphism is a Risk Factor for Preeclampsia Development
Author(s) -
Pontillo Alessandra,
Reis Edione C.,
Bricher Pamela N.,
Vianna Priscila,
Diniz Solange,
Fernandes Karla S.,
Chies Jose A.,
Sandrim Valeria
Publication year - 2015
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12353
Subject(s) - inflammasome , preeclampsia , pathogenesis , nlrp1 , polymorphism (computer science) , secretion , allele , medicine , gene , receptor , immunology , genetics , biology , pregnancy , caspase , apoptosis , programmed cell death
Problem Augmented levels of IL‐1ß have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro‐IL1ß cleavage and IL‐1ß secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome' genes and preeclampsia. Method of study Selected polymorphisms in inflammasome genes ( NLRP1, NLRP3, CARD8 , and IL1B ) were analyzed in 286 Brazilian women with and 309 without preeclampsia. Results and Conlclusions The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR = 1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.