Premium
The Placental Immune Milieu is Characterized by a Th2‐ and Anti‐Inflammatory Transcription Profile, Regardless of Maternal Allergy, and Associates with Neonatal Immunity
Author(s) -
Abelius Martina S.,
Janefjord Camilla,
Ernerudh Jan,
Berg Göran,
Matthiesen Leif,
Duchén Karel,
Nilsson Lennart J.,
Jenmalm Maria C.
Publication year - 2015
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12350
Subject(s) - immunity , immune system , allergy , immunology , transcription (linguistics) , inflammation , pregnancy , medicine , biology , genetics , linguistics , philosophy
Problem How maternal allergy affects the systemic and local immunological environment during pregnancy and the immune development of the offspring is unclear. Method of study Expression of 40 genes was quantified by PCR arrays in placenta, peripheral blood mononuclear cells ( PBMC ), and cord blood mononuclear cells ( CBMC ) from 7 allergic and 12 non‐allergic women and their offspring. Results Placental gene expression was dominated by a T h2‐/anti‐inflammatory profile, irrespectively of maternal allergy, as compared to gene expression in PBMC . p35 expression in placenta correlated with fetal T bx21 (ρ = −0.88, P < 0.001) and IL ‐5 expression in PBMC with fetal galectin1 (ρ = 0.91, P < 0.001). Increased expression of T h2‐associated CCL 22 in CBMC preceded allergy development. Conclusions Gene expression locally and systemically during pregnancy was partly associated with the offspring's gene expression, possibly indicating that the immunological milieu is important for fetal immune development. Maternal allergy was not associated with an enhanced T h2 immunity in placenta or PBMC , while a marked prenatal T h2 skewing, shown as increased CCL 22 m RNA expression, might contribute to postnatal allergy development.