Changes in Maternal Blood Inflammatory Markers As a Predictor Of Chorioamnionitis: A Prospective Multicenter Study

Problem To evaluate the inflammatory pattern in maternal circulation from women with preterm premature rupture of membranes ( PPROM ) considering the occurrence of histologically confirmed chorioamnionitis ( HCA ). Method of study A prospective study was conducted in 121 women with PPROM between 24 and 34 + 0 weeks of gestation. Association between white blood cells ( WBC ) count, plasma CRP , IL ‐6, MCP ‐1 and IP ‐10 levels, and HCA was assessed. Results The rate of HCA was 44.7% (54/121). During the 5 days preceding delivery, median CRP , WBC , and IL ‐6 levels were significantly higher in the HCA than in no‐ HCA group ( P  < 0.001). Variations in IL ‐6, IP ‐10 levels, during the 24–72 hr before delivery, were predictors of the occurrence of HCA , but the diagnostic accuracy was low [Receiver Operating Characterictic ( ROC ) curve, area under the curve ( AUC ) = 0.56]. Conclusion An increase in IL ‐6, CRP , IP ‐10 maternal plasma levels was confirmed in PPROM women with HCA . Longitudinal follow‐up of these markers did not add valuable information regarding HCA .