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Association of Increased S100A8 Serum Protein with Early Pregnancy Loss
Author(s) -
Nair Rohini R.,
Khanna Anuradha,
Singh Kiran
Publication year - 2015
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12318
Subject(s) - s100a8 , pregnancy , menstrual cycle , decidua , medicine , menstruation , immunology , physiology , endocrinology , andrology , obstetrics , fetus , biology , inflammation , placenta , hormone , genetics
Problem The contribution of systemic S100A8 protein in menstrual cycle, pregnancy, and early pregnancy loss ( EPL ) is not known. Altered expression of S100A8 in maternal decidua is associated with recurrent early pregnancy loss. The objective of this study was to investigate the systemic level of S100A8 in different phases of menstrual cycle, different trimester of pregnancy, and in EPL . Method of Study Level of S100A8 was investigated in serum samples of the subjects through enzyme‐linked immunosorbent assay ( ELISA ). Result and Conclusion S100A8 levels were elevated during proliferative phase of menstural cycle. We found no statistical difference in S100A8 level in different trimester of pregnancy. S100A8 level was found to be significantly elevated in patients with EPL . This is the first study evaluating the systemic level of S100A8 predicting its role during menstural cycle and pregnancy. It opens a new perspective in which S100A8 can be used as a prognostic marker for EPL .