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Temporal Variation in Soluble Human Leukocyte Antigen‐G (sHLA‐G) and Pregnancy‐Associated Plasma Protein A (PAPP‐A) in Pregnancies Complicated by Gestational Diabetes Mellitus and in Controls
Author(s) -
Beneventi Fausta,
Simonetta Margherita,
Locatelli Elena,
Cavagnoli Chiara,
Badulli Carla,
Lovati Elisabetta,
Garbin Giulia,
Genini Emilia,
Albertini Riccardo,
Tinelli Carmine,
Martinetti Miryam,
Spinillo Arsenio
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12270
Subject(s) - pregnancy , gestational diabetes , gestation , medicine , pregnancy associated plasma protein a , obstetrics , prospective cohort study , first trimester , gestational age , diabetes mellitus , second trimester , gynecology , endocrinology , biology , genetics
Problem To target gestational diabetes mellitus (GDM) by means of temporal variation in pregnancy‐associated plasma protein A (PAPP‐A) and soluble human leukocyte antigen‐G (sHLA‐G). Method of study Retrospective analysis of PAPP‐A and sHLA‐G blood levels in historical samples of 112 GDM and 112 controls, drawn at first trimester, and prospective study in 18 GDM and 105 controls collected in triplicate along the pregnancy. Six hundred and sixty‐five samples were analyzed. Results Gestational diabetes mellitus had significantly lower first‐trimester PAPP‐A concentrations than controls (2343 ± 1519 versus 2996 ± 1955 mU/mL, in retrospective brunch and 2490.57 ± 1828.52 versus 3240.84 ± 1930.69 mU/L in prospective one, P < 0.001). First‐trimester sHLA‐G level was significantly lower in GDM than in controls (52.88 ± 59.69 versus 66.81 ± 50.14 ng/mL, P < 0.001) and increased during gestation in diabetic women showing an opposite trend with respect to the controls. Conclusion PAPP‐A and sHLA‐G are independent markers of GDM. Quantitative variations during pregnancy help to early unravel the onset of GDM.