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Longitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy
Author(s) -
Ferguson Kelly K.,
McElrath Thomas F.,
Chen YinHsiu,
Mukherjee Bhramar,
Meeker John D.
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12265
Subject(s) - medicine , odds ratio , preeclampsia , pregnancy , obstetrics , premature rupture of membranes , premature birth , etiology , gestational age , c reactive protein , case control study , inflammation , immunology , biology , genetics
Problem Previous studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy. Method of study We explored longitudinal changes in plasma cytokines, including IL ‐1β, IL ‐6, IL ‐10, and TNF ‐α, as well as C‐reactive protein in pregnant women from a nested case–control study. Results IL ‐6 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and/or preterm premature rupture of the membranes. Associations were strongest later in pregnancy. IL ‐10 was associated with increased odds of placentally mediated preterm birth, defined by presentation with preeclampsia or intrauterine growth restriction, and odds ratios were also highest near the end of pregnancy. Conclusion Maternal inflammation markers were associated with increased risk of preterm birth, and relationships differed by etiology of preterm delivery and gestational age at sample collection.