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Bacterial Vaginosis and the Cervicovaginal Immune Response
Author(s) -
Mitchell Caroline,
Marrazzo Jeanne
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12264
Subject(s) - bacterial vaginosis , immune system , immunology , vagina , immunity , human immunodeficiency virus (hiv) , inflammation , inflammatory response , biology , medicine , microbiology and biotechnology , genetics
Bacterial vaginosis ( BV ) is a common cause of vaginal discharge in reproductive age women around the world and is associated with several poor reproductive health outcomes, including HIV ‐1 acquisition. One possible mechanism for this association is the inflammatory immune response induced by BV in the cervical and vaginal mucosae. There is significant heterogeneity in reports of markers of cervicovaginal inflammation in women with BV , likely due to microbial and host diversity, as well as differences in study design. In this article, we review the characteristics of the mucosal immune response in BV , the potential role of lactobacilli in modulating that response, and the impact of individual BV ‐associated bacterial species on mucosal immunity. We focus on inflammatory markers that are proposed to increase the risk of HIV ‐1 acquisition.