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Secreted Mucosal Antimicrobials in the Female Reproductive Tract that are Important to Consider for HIV Prevention
Author(s) -
Ghosh Mimi
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12250
Subject(s) - female reproductive tract , reproductive tract , antimicrobial , human immunodeficiency virus (hiv) , biology , broad spectrum , secretion , hormone , endogeny , immunology , medicine , microbiology and biotechnology , uterus , endocrinology , chemistry , combinatorial chemistry
The mucosal microenvironment of the female reproductive tract ( FRT ) is rich in secreted endogenous antimicrobials that provide the first line of defense against pathogens. This review focuses on the spectrum of secreted antimicrobials found in the FRT that have anti‐ HIV functions and are regulated by the natural hormonal changes in women's life cycle. Understanding the complex nature of FRT , mucosal microenvironment will enable us to better design therapeutic interventions for women against sexually transmitted pathogens.