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New Insights into the Relationship between Viral Infection and Pregnancy Complications
Author(s) -
Kwon JaYoung,
Romero Roberto,
Mor Gil
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12243
Subject(s) - trophoblast , pregnancy , preeclampsia , viral infection , clinical significance , immunology , medicine , placenta , virus , obstetrics , biology , fetus , genetics
A recent study by M c D onnold and coinvestigators published in A m J O bstet G ynecol reports an association between human papillomavirus ( HPV ) infection and preeclampsia. The investigation was based on the hypothesis that HPV trophoblast infection results in failed trophoblast invasion, and placental dysfunction and hypoxia. The findings from this study along with previous data addressing the relationship between viral infection and obstetrical complications highlight the relevance of viral infection during pregnancy. A better understanding of mechanisms via which virus leads to pregnancy complications will drive us closer to finding a strategy to prevent adverse outcomes.