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Lipoxin A4: The Double‐edge Sword in Mice Pregnancy
Author(s) -
Xu Zhangye,
Zhao Feng,
Xiang Huiqiu,
Wang Ni,
Ye Duyun,
Huang Yinping
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12242
Subject(s) - pregnancy , uterus , blastocyst , abortion , medicine , trophoblast , endocrinology , placenta , andrology , embryo , fetus , biology , microbiology and biotechnology , embryogenesis , genetics
Problem To evaluate the role for LXA 4 in the pregnancy. Method of study We detected the changes of LXA 4 and LXA 4 biosynthetic enzymes in the mice's pregnancy, blocked LXA 4 signaling pathway, managed LXA 4 level, and treated LPS ‐induced mouse abortion model to systematically determine how LXA 4 impact pregnancy. Results The concentrations of LXA 4 in serum and uterus were lowest on Days 4.5 of pregnancy and in labor as compared to Day 12.5 of pregnancy (270.2 ± 33.2, 277.5 ± 23.7 versus 457.1 ± 40.9 pg/mL). Inhibition of the LXA 4 signaling pathway did not affect pregnancy during the peri‐implantation period of pregnancy, but induced abortion when administered after implantation of blastocysts. High levels of LXA 4 interfered with implantation, but protected mice from aborting in response to LPS . Conclusion LXA 4 might be involved in the process of pregnancy, and LXA 4 might act as the double‐edge sword in pregnancy: the anti‐implantation effect in the stage of peri‐implantation and the anti‐abortion affect after blastocyst implantation.

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