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Polymorphisms in Inflammatory Genes are Associated with Term Small for Gestational Age and Preeclampsia
Author(s) -
Harmon Quaker E.,
Engel Stephanie M.,
Wu Michael C.,
Moran Thomas M.,
Luo Jingchun,
Stuebe Alison M.,
Avery Christy L.,
Olshan Andrew F.
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12241
Subject(s) - preeclampsia , snp , single nucleotide polymorphism , biology , pregnancy , genetic association , candidate gene , immunology , gene , genetics , medicine , genotype
Problem Inflammatory biomarkers are associated with preeclampsia ( PE ) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of A frican A merican mothers. Method of study Cases and controls ( N = 1646) from a pregnancy cohort were genotyped for 503 tag SNP s in 40 genes related to inflammation. Gene‐set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets. Results Gene‐level associations were found for IL 6 and KLRD 1 for term small for gestational age ( SGA ) among African Americans. LTA / TNF and TBX 21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8 (95% CI 1.1–2.7). Conclusion Although previous studies have suggested null associations, increased tagging and stratification by genetic ancestry suggests important associations between IL 6 and term SGA for African Americans, and a TNF regulator and PE among European Americans ( N = 149).