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CMV Infection, TLR ‐2 and ‐4 Expression, and Cytokine Profiles in Early‐Onset Preeclampsia with HELLP Syndrome
Author(s) -
Xie Fang,
Dadelszen Peter,
Nadeau Joseph
Publication year - 2014
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12199
Subject(s) - hellp syndrome , preeclampsia , pregnancy , immunology , medicine , cytokine , immune system , biology , genetics
Problem Cytomegalovirus ( CMV ) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll‐like receptor ( TLR ) expression in early‐onset preeclampsia ( EOPE ) with hemolysis, elevated liver enzyme and low platelets syndrome ( HELLP s) are unexplored. Method of study A case–control study was performed to examine maternal CMV antibodies, neutrophil Toll‐like receptor ( TLR )‐2 and ‐4 expression as well as the cytokine profile in EOPE with HELLP s ( EOPE ‐ HELLP s) ( n = 10), late‐onset preeclampsia ( LOPE ) ( n = 20), normal pregnancy ( n = 60), and non‐pregnancy ( n = 20) controls. Results EOPE ‐ HELLP s had significantly increased CMV I g G sero‐positivity, upregulated TLR ‐2/‐4 m RNA expression, increased serum IL ‐6 and TNF ‐α, and reduced IL ‐10 compared with matched normal and non‐pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls. Conclusion We observed a significant association between CMV IgG sero‐positivity and innate immune response in EOPE ‐ HELLP s. Our data suggest that CMV infection may be a risk factor for this disorder.