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Cytokine Patterns Differ Seasonally between Women with and without Uterine Leiomyomata
Author(s) -
Wegienka Ganesa,
Day Baird Donna,
Cooper Tracy,
Woodcroft Kimberley J.,
Havstad Suzanne
Publication year - 2013
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12127
Subject(s) - leiomyoma , uterine leiomyoma , immune system , cytokine , medicine , monocyte , gynecology , physiology , endocrinology , biology , immunology , pathology
Problem Uterine leiomyomata are the most common reproductive tumor in women, and their cause is not known. Methods of Study Plasma samples from 155 women (74 with and 81 without ultrasound‐confirmed leiomyoma) from a new study of leiomyoma risk factors in the Detroit, Michigan area, were examined for any cross‐sectional associations between commonly examined cytokines and leiomyoma presence. Results Associations varied by season of sample collection defined a priori as winter (December–February) and non‐winter seasons. In the winter months, interleukin (IL)13 and IL 17 were positively and IP 10 was inversely associated with having a leiomyoma. In the non‐winter samples, VEGF , G‐ CSF , and IP 10 were positively associated and Monocyte chemotactic protein‐1, IL 13, and IL 17 were inversely associated with having a leiomyoma. Associations were not changed by adjustment for age or BMI . Conclusions These data suggest that new insight into leiomyoma formation may be acquired through investigation of the immune system.