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Thyroid Function in Infertile Patients Undergoing Assisted Reproduction
Author(s) -
Fumarola Angela,
Grani Giorgio,
Romanzi Daniela,
Del Sordo Marianna,
Bianchini Marta,
Aragona Alessia,
Tranquilli Daniela,
Aragona Cesare
Publication year - 2013
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12113
Subject(s) - infertility , pregnancy , thyroid function , reproduction , thyroid , medicine , live birth , endocrine system , embryo transfer , assisted reproductive technology , thyroid disease , gynecology , andrology , obstetrics , biology , endocrinology , hormone , ecology , genetics
Problem Thyroid disease is one of the most common endocrine conditions affecting women during reproductive age. A link between thyroid and assisted reproduction outcome is debated. Method of study Serum TSH levels, number and scoring of oocytes and embryos, and number of clinical pregnancies were retrospectively recorded in 164 women undergoing assisted reproduction technologies (ART) at an U niversity–based fertility center, to evaluate the outcome of the first steps of assisted reproduction (ovarian stimulation, oocyte pickup and fertilization, embryo transfer and implantation) in relation to thyroid function and autoimmunity. Results No significant relationship was found between TSH and all parameters, except clinical pregnancy rate (22.3% in TSH ≤ 2.5 group versus 8.9% in TSH > 2.5 m UI / L group; P = 0.045). No pregnancy occurred in women with anti‐thyroperoxidase autoantibodies, while pregnancy occurred in 23.9% of cycles without autoimmunity ( P = 0.02). Conclusion Further studies must be conducted in order to shed light on the link between infertility and thyroid dysfunction.