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Expression of Apoptosis in Placenta of Experimental Antiphospholipid Syndrome Mouse
Author(s) -
Velayuthaprabhu Shanmugam,
Matsubayashi Hidehiko,
Sugi Toshitaka,
Nakamura Masato,
Ohnishi Yasuyuki,
Ogura Tomoyuki,
Archunan Govindaraju
Publication year - 2013
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12084
Subject(s) - placenta , antiphospholipid syndrome , apoptosis , trophoblast , andrology , pregnancy , histopathology , fetus , biology , pathological , medicine , immunology , pathology , antibody , biochemistry , genetics
Problem To study the histopathology and expression of apoptosis in placenta of pregnancy‐complicated antiphospholipid syndrome (APS)‐positive mouse models. Method of study ICR mice were immunized with IgG isotype of human anticardiolipin (aCL) and/or lupus anticoagulant (LA). The pathological and apoptotic expression was studied in the placenta of positive APS mice and compared with respective control samples. Results Mice with passive immunization of human aCL and/or LA produced an increase in fetal resorption along with markedly induced thrombosis in the placenta associated with increased placental apoptosis. In addition, fewer mitotic cells, less trophoblast giant cell invasion, and more shrunken cells in the deciduas were seen. Conclusion Our study showed the pathogenic role of aCL and LA in pregnancy complications.