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Decidual Regulatory T Cells in Placental Pathology and Pregnancy Complications
Author(s) -
Quinn Kristen H.,
Parast Mana M.
Publication year - 2013
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12077
Subject(s) - placenta , fetus , pregnancy , decidua , in utero , gestation , immunology , biology , medicine , andrology , genetics
Regulatory T cells ( T regs) have been identified as immunomodulatory cells, which induce tolerance. Evidence from numerous recent studies implicates these cells as critical for maternal tolerance to the fetal‐derived placenta, proper functioning of which is required for normal gestation and growth and development of the fetus in utero . This review focuses on the recent studies of T regs at the maternal–fetal interface in pregnancy complications, as well as their identification in specific inflammatory lesions in the placenta.