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Association Between Maternal and Fetal TLR 4 (896A>G, 1196C>T) Gene Polymorphisms and the Risk of Pre‐term Birth in the Polish Population
Author(s) -
Bitner Adam,
Sobala Wojciech,
Kalinka Jarosław
Publication year - 2013
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1111/aji.12068
Subject(s) - carriage , fetus , allele , medicine , pregnancy , gestation , population , obstetrics , allele frequency , polymorphism (computer science) , immunology , gene , biology , genetics , pathology , environmental health
Problem Bacteria activates Toll‐like receptor 4 on immune system cells leading to preterm birth ( PTB ). The aim of study was to evaluate the impact of maternal and fetal carriage of TLR 4 gene polymorphisms on the risk of PTB . Method of Study Frequency of TLR 4 (896A>G, 1196C>T) variants was determined in 121 women who delivered preterm, 152 women who delivered at term, 49 term newborns and 35 preterm newborns with the use of PCR ‐ RFLP . Results We found no associations between frequency of TLR 4 polymorphic alleles in mothers and fetuses and the risk of delivery before 37th week of pregnancy. However significantly lower frequency of TLR 4 1196T allele was observed in subgroup of mothers who delivered before 33rd week comparing with those who delivered later (4,4% versus 14,2%, OR = 0,28 (95% CI : 0,04–0,99). Conclusions Maternal carriage of TLR 4 1196T allele may be associated with reduced risk of PTB before 33rd week of gestation in Polish population.