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Topical epigallocatechin‐3‐gallate in the treatment of vitiligo
Author(s) -
Hu Wenting,
Zhang Lingling,
Lin Fuquan,
Lei Jiehao,
Zhou Miaoni,
Xu AiE
Publication year - 2021
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13612
Subject(s) - pimecrolimus , medicine , vitiligo , dermatology , lesion , side effect (computer science) , target lesion , significant difference , tacrolimus , surgery , transplantation , percutaneous coronary intervention , myocardial infarction , computer science , programming language
Objective To preliminarily assess the efficacy and safety of the topical application of Epigallocatechin‐3‐gallate (EGCG) in treating vitiligo, a 6‐month clinical trial was carried out. Method Patients were randomly given topical application of EGCG on the assigned lesions, with pimecrolimus being used as the control for twice a day over a 6‐month treatment period. Responses to treatment were assessed based on the changes in VASI score for percentage reduction in body surface area and the PGA scores. Results According to our results, both drugs were discovered to be markedly effective on repigmentation. The VASI of lesion had diminished from 1.19 ± 0.42 to 0.63 ± 0.38, in the EGCG‐treated lesions, while from 1.18 ± 0.43 to 0.61 ± 0.36 in the pimecrolimus‐treated lesions, and there was no statistically significant difference in VASI score between the EGCG‐treated lesions and pimecrolimus‐treated lesions ( P = 0.755). Meanwhile, the mean PGA score on the EGCG applied side was 4.39 ± 2.23, while that was 4.43 ± 2.02 on the pimecrolimus applied side ( P = 0.886). Furthermore, difference in the improvement degree between pimecrolimus side and EGCG side was not statistically significant ( P = 0.845). Notably, no serious side effects were observed throughout the study. Conclusion Findings of the study indicate that topical EGCG can be effective on treating vitiligo.