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Cutaneous‐group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases
Author(s) -
Bonometti Arturo,
Gliozzo Jessica,
Moltrasio Chiara,
Bagnoli Filippo,
Berti Emilio
Publication year - 2021
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13491
Subject(s) - medicine , histiocytosis , myeloid , pathology , bone marrow , pathological , concomitant , malignant histiocytosis , dermatology , histiocyte , disease
Background Histiocytoses are haematological disorders of bone marrow origin that share many biological and clinical features with haematological neoplasms. The association between histiocytoses of the cutaneous‐group and myeloid malignancies is a poorly investigated topic of high biological and clinical impact. Methods We performed a systematic review of the scientific literature, compliant with PRISMA guidelines, to unravel the clinical and pathological features of this intriguing association. Findings We gathered and analysed 102 patients. Most were children with generalised cutaneous eruptions and displayed risk organ involvement (i.e. bone marrow, spleen, liver). Interestingly, all these features are uncommonly encountered in C‐group histiocytosis not associated with haematological neoplasms. Conclusions Our review shows that generalised eruptions and risk organ involvement in cutaneous‐group histiocytosis should raise a suspicion for a concomitant myeloid neoplasm both in children and in adults and warrant further investigations. A rapid recognition of this association is required to start a prompt and effective therapeutic management given the aggressive behaviour of the associated myeloid neoplasm in most instances.