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A review of actinic keratosis, skin field cancerisation and the efficacy of topical therapies
Author(s) -
Sinclair Robert,
Baker Christopher,
Spelman Lynda,
Supranowicz Madeleine,
MacMahon Beth
Publication year - 2021
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13447
Subject(s) - actinic keratosis , medicine , dermatology , keratosis , population , incidence (geometry) , pathology , environmental health , basal cell , physics , optics
While a wide range of treatments exist for actinic keratosis and skin field cancerisation, the long‐term benefits of the most common topical therapies are poorly defined. This report reviews the efficacy of the most commonly used topical therapies to treat regional or field lesions. Limited clinical and histopathological data are available on clearance rates at 12 months post‐treatment for the most commonly used agents, with varied outcome measures making any comparison difficult. In general, total field clearance rates at 12 months are suboptimal for the most commonly employed agents. Given the increasing incidence of actinic keratosis and skin field cancerisation due to an ageing population, further research into the efficacy of therapies is critical to guide treatment choice.