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BAP1‐inactivated melanocytic tumour with borderline histopathological features (BAP1‐inactivated melanocytoma): A case report and a reappraisal
Author(s) -
Ferrara Gerardo,
Mariani Maria Paola,
Auriemma Matteo
Publication year - 2021
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13408
Subject(s) - bap1 , medicine , pleomorphism (cytology) , melanocytoma , pathology , melanoma , melanocytic nevus , dermatology , nevus , cancer research , immunohistochemistry
We describe a case of BRCA1‐associated protein (BAP1)‐inactivated melanocytic tumour (BIMT) in a 22‐year‐old woman, documenting for the first time with dermoscopy its sudden development with the onset of an atypical vascular pattern within a Miescher naevus. The tumour was histopathologically atypical because of the presence of confluent pleomorphism, solid sheets of cells and grouped mitotic figures: these features were consistent with a melanocytic neoplasm with intermediate morphology (‘BAP1‐inactivated melanocytoma’; BIM) between a BAP1‐inactivated melanocytic naevus and a BAP1‐inactivated melanoma. The atypical histopathological features of the present case were different from the criteria quoted for BIM in the World Health Organization 2018 classification of skin tumours.