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Assessment of 5‐Aminolaevulinic Acid Photodynamic Therapy (ALA‐PDT) in Chinese patients with actinic keratosis: Correlation of dermoscopic features with histopathology
Author(s) -
Jin Qiuzi,
Li Weiwei,
Wu Wenting,
Zhang Hua,
Zhao Fang,
Zhang Qian,
Zhang Chunlei
Publication year - 2020
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13289
Subject(s) - actinic keratosis , medicine , keratosis , photodynamic therapy , hyperkeratosis , dermatology , histopathology , dermatoscopy , parakeratosis , pathological , pathology , basal cell , melanoma , chemistry , organic chemistry , cancer research
Objectives The study examines the changes in dermoscopic features of actinic keratosis (AK) after photodynamic therapy, and delineates the association between AK dermoscopic and histopathological findings. Methods A total of 21 patients (23 lesions) with pathologically confirmed actinic keratosis who received 5‐aminolaevulinic acid (ALA) photodynamic therapy (ALA‐PDT) were enrolled. The numbers of PDT treatments were: 1, n = 1; 2, n = 2; 3, n = 10; 4, n = 6; 5, n = 2; 6, n = 2). The dermoscopic features before and after the PDT were compared. Results There were statistically significant decreases in the positive rates of dermoscopic features including scales ( P < 0.001), follicular plugs with whitish halo ( P = 0.013), and red pseudonetwork ( P = 0.022) among patients treated with ALA‐PDT. Dermoscopic feature was significantly associated with pathological grade ( P < 0.001). Histopathological hyperkeratosis was significantly associated with dermoscopic red pseudonetwork ( P = 0.034) and wavy vessel ( P = 0.005). Parakeratosis was associated with wavy vessels ( P = 0.001). For vascular hyperplasia in dermal papillae, the significant correlates included scales ( P = 0.011), follicular plugs with whitish halo ( P = 0.011), red pseudonetwork ( P < 0.001); coiled vessels ( P = 0.003) and rosette sign ( P = 0.004). Wavy vessels was the only feature correlating keratosis pilaris ( P = 0.003). Conclusions The findings of the present study support dermoscopy as having potential to be useful for diagnosing and monitoring of actinic keratosis.