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Linear IgA bullous dermatosis associated with ulcerative colitis: A case report and literature review
Author(s) -
Kanda Naoko,
Nakadaira Nanami,
Otsuka Yohei,
Ishii Norito,
Hoashi Toshihiko,
Saeki Hidehisa
Publication year - 2020
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13121
Subject(s) - ulcerative colitis , medicine , pathology , antigen , immunoglobulin a , basement membrane , immunology , direct fluorescent antibody , immunofluorescence , dermis , dermatology , antibody , immunoglobulin g , disease
We report the case of a 59‐year‐old Japanese woman who developed linear IgA bullous dermatosis during treatment for ulcerative colitis that manifested as pruritic vesicles with erythema on the trunk and scalp. Histopathological examination revealed subepidermal bulla with neutrophil and eosinophil infiltration in the upper dermis. Direct immunofluorescence revealed linear IgA deposits at the basement membrane zone, and indirect immunofluorescence using split skin revealed IgA reaction to the epidermal side (lamina lucida type). We reviewed 33 reported cases of linear IgA bullous dermatosis associated with ulcerative colitis and found that ulcerative colitis preceded the onset of linear IgA bullous dermatosis in 94% of the patients and that IgA‐positive patients in split skin indirect immunofluorescence all showed the lamina lucida type, indicating that target antigens for serum IgA antibodies may reside in the lamina lucida. Regarding the pathogenetic association of ulcerative colitis and linear IgA bullous dermatosis, intestinal inflammation may induce the exposure and presentation of intestinal antigens that are cross‐reactive to cutaneous antigens, stimulating autoimmune response to antigens of cutaneous basement membrane zones.