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A gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: An update
Author(s) -
Li Xueli,
Jiang Lei,
Huang Yong,
Ren Zhilong,
Liang Xiaoqin,
Wang Peng
Publication year - 2020
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13107
Subject(s) - hidradenitis suppurativa , medicine , pathogenesis , etiology , dermatology , disease , immunology , pathology
Hidradenitis suppurativa is a chronic skin disease characterised by repeated skin abscesses with sinus tracts and scar formation. Currently, the aetiology and pathogenesis of hidradenitis suppurativa remain unclear. Genetic factors, immune disorders, hormonal abnormalities, skin‐microbial dysbiosis, smoking, obesity and mechanical friction all influence hidradenitis suppurativa pathogenesis. Moreover, hidradenitis suppurativa has a familial subset with autosomal dominant transmission proposed and is related to a mutation of γ‐secretase component genes. In this review, we analyse and summarise research progress regarding the relationship between the γ‐secretase gene dysfunction and the pathogenesis of hidradenitis suppurativa.