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Merkel cell carcinoma in situ : New insights into the cells of origin
Author(s) -
Yang Anes,
Cordoba Carolina,
Cheung Karen,
Konya Joseph
Publication year - 2019
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13068
Subject(s) - merkel cell carcinoma , pathology , histopathology , synaptophysin , merkel cell polyomavirus , carcinoma , medicine , merkel cell , immunohistochemistry
We report a case of a 71‐year‐old male who presented with a small skin‐coloured plaque on his cheek. Histopathology demonstrated an intraepidermal carcinoma with follicular involvement. No evidence of dermal invasion was seen. Immunohistochemical studies showed areas of positive staining for CK 20, EMA and synaptophysin. Histopathology findings were found to be most consistent with a diagnosis of intraepidermal carcinoma with features of Merkel cell carcinoma in situ, in combination with a squamous cell carcinoma in situ , with follicular involvement. Recent advances and findings suggest Merkel cell polyomavirus MCP yV‐positive Merkel cell carcinoma and MCP yV‐negative Merkel cell carcinoma have different cells of origin from different germ layers.