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Resolution of acenocoumarol‐associated calciphylaxis with drug withdrawal
Author(s) -
SuárezPeñaranda JoséManuel,
Minasyan Anna,
SainzGaspar Laura,
SánchezAguilar MaríaDolores
Publication year - 2019
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.13006
Subject(s) - acenocoumarol , calciphylaxis , medicine , drug , intensive care medicine , surgery , pharmacology , warfarin , calcification , atrial fibrillation
Calciphylaxis is a syndrome of cutaneous ischaemic necrosis and ulceration due to arteriolar calcification with subsequent thrombosis, which rarely presents in patients without terminal kidney disease. Recently, several reports of coumarins‐associated calciphylaxis have stressed the relevance of anticoagulant therapy as an important risk factor for the development of this condition. We report five cases of acenocoumarol‐associated, biopsy‐proven calciphylaxis in women aged between 64 and 92 years. The drug had been prescribed for atrial fibrillation and was taken without interruption from 14 to 224 months. Lesions were present for months in all cases and were resistant to multiple therapeutic options, but they resolved only with simple wound care measures 6–14 months after changing the anticoagulant therapy.