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Nonclassical pemphigus with exclusively IgG anti‐desmocollin 3‐specific antibodies
Author(s) -
Iranzo Pilar,
Ishii Norito,
Hashimoto Takashi,
AlsinaGibert Mercé
Publication year - 2019
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12991
Subject(s) - desmoglein , pemphigus , antibody , medicine , recombinant dna , immunology , immunoglobulin g , paraneoplastic pemphigus , autoantibody , biology , genetics , gene
Abstract We describe a patient with nonclassical clinical and histopathological features of pemphigus with exclusively IgG antibodies against desmocollin (Dsc) 3 detected by enzyme‐linked immunosorbent assay of recombinant eukaryotic protein of Dsc1‐Dsc3. The absence of antibodies against other known targets, such as desmogleins, reinforces the role of anti‐Dsc antibodies in the pathophysiology of atypical pemphigus.