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Angina bullosa haemorrhagica‐like lesions in pemphigus vulgaris
Author(s) -
Balighi Kamran,
Daneshpazhooh Maryam,
Aghazadeh Nessa,
Rahbar Ziba,
Mahmoudi Hamidreza,
Sadjadi Adele
Publication year - 2019
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12923
Subject(s) - medicine , pemphigus vulgaris , dermatology , angina , pemphigus , cardiology , myocardial infarction
Background/Objectives The aim of this study was to describe a previously unreported association of oral pemphigus vulgaris with short‐lived blood‐filled painless blisters resembling angina bullosa haemorrhagica ( ABH ). Methods A cross‐sectional study of consecutive patients with Pemphigus vulgaris. All patients were examined for the presence of ABH ‐like lesions, and demographic, clinical and histopathological data were collected. Histopathological examination was performed when feasible. Results A total of 318 with pemphigus vulgaris were included (63.5% female, mean age: 46 years). ABH ‐like lesions were present in 82 (25.8%) patients, commonly observed in the buccal mucosa (47, 57.3%) followed by the palate (15, 18.3%). All patients had normal platelet counts with no evidence of bleeding diathesis. Biopsies of the ABH ‐like lesions showed suprabasal clefts in four of six samples. ABH ‐like lesions were significantly associated with partial remission of pemphigus vulgaris (47.5%, P = 0.002) and the use of intraoral steroids ( P = 0.001, odds ratio: 5.9 [95% confidence interval: 2.5–13.6]). Conclusion ABH ‐like lesions may represent a transient or abortive form of oral pemphigus vulgaris and tend to have a benign and self‐limiting nature.