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Multiple perianal ulcers due to suppositories
Author(s) -
Savoia Francesco,
Sechi Andrea,
Tabanelli Michela,
Zago Silvia,
Leuzzi Miriam,
Baraldi Carlotta,
Patrizi Annalisa
Publication year - 2019
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12888
Subject(s) - medicine , analgesic , vasoconstriction , caffeine , anesthesia , migraine , prochlorperazine , dermatology , surgery , nausea
Abstract We report a case of long‐standing inexplicable perianal ulcers. After exclusion of an inflammatory, infectious or neoplastic origin, a thorough personal history revealed that for many years the patient had been using analgesic suppositories containing indomethacin, caffeine, and prochlorperazine dimaleate, four to five times a week, for migraine. On stopping the suppositories, there was complete healing within 12 weeks. We hypothesize that vasoconstriction and vascular damage were the pathogenetic mechanisms behind the perianal ulcers.