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Treatment of severe recalcitrant pyoderma gangrenosum with ustekinumab
Author(s) -
Low Zhi Mei,
Mar Adrian
Publication year - 2018
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12744
Subject(s) - pyoderma gangrenosum , ustekinumab , medicine , dermatology , interleukin 23 , interleukin , disease , cytokine , infliximab
An increased expression of interleukin‐23 has been observed in patients with pyoderma gangrenosum, leading to the use of ustekinumab as a therapeutic option. We report the successful use of ustekinumab in three patients with treatment‐resistant pyoderma gangrenosum of varying clinical presentations.