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Frequent immunoglobulin G4 expression in a common variant of primary cutaneous marginal zone B‐cell lymphoma
Author(s) -
Sun Jing Ru,
g Lin,
Liu Xiao Qing,
Tu Ping,
Wang Yang
Publication year - 2018
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12699
Subject(s) - marginal zone , lymphoma , medicine , pathology , marginal zone b cell lymphoma , polyclonal antibodies , infiltration (hvac) , antibody , lymphoplasmacytic lymphoma , histopathology , b cell , fibrosis , immunology , waldenstrom macroglobulinemia , physics , thermodynamics
Immunoglobulin (Ig)G4 expression was recently observed in a proportion of primary cutaneous marginal zone B‐cell lymphoma (PCMZL) with plasmacytic differentiation. IgG4‐related disease is characterised by polyclonal lymphoplasmacytic infiltration with IgG4 expression, storiform fibrosis and obliterative phlebitis in histopathology. Here we report three cases of common variants of PCMZL with predominant and varied IgG4 expression, suggesting there is an underlying clonal progression between these two entities.