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Multiple cutaneous reticulohistiocytosis with T‐cell large granular lymphocyte clonopathy
Author(s) -
Papadantonakis Pavlos,
Kaparou Maria,
Papadaki Helen A,
Marinos Leonidas,
Krasagakis Konstantin
Publication year - 2017
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12608
Subject(s) - lymphocytosis , atypical lymphocyte , medicine , histiocyte , pathology , histiocytosis , giant cell , immunophenotyping , eosinophilic , asymptomatic , skin biopsy , bone marrow , infiltration (hvac) , population , biopsy , lymphocyte , immunology , lymphoma , antigen , physics , disease , environmental health , thermodynamics
A 63‐year‐old Caucasian man presented with a 4‐month history of disseminated asymptomatic reddish‐brown papulonodular lesions. A skin biopsy showed dermal infiltration with CD 68 + histiocytes, predominantly with eosinophilic cytoplasm, some with a ground‐glass cytoplasm, and a small number of giant cells. The diagnosis of multiple cutaneous reticulohistiocytosis was made. Bone marrow immunophenotyping due to peripheral blood lymphocytosis revealed the presence of a monoclonal population of CD 3 + , CD 8 + CD 57 + large granular lymphocytes. The present case suggests the coexistence of multiple cutaneous reticulohistiocytosis with an underlying disorder.