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Palmoplantar keratoses and B owen's disease in a V ietnam veteran: Could A gent B lue be implicated?
Author(s) -
Cognetta Armand B,
Wolfe Christopher M,
Herbst Alexander T
Publication year - 2016
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12387
Subject(s) - hyperkeratosis , medicine , palmoplantar keratoderma , dyskeratosis , dermatology , basal cell , pathology
A gent B lue was an arsenical herbicide used extensively in the V ietnam W ar. Arsenic is one of the known causes of acquired palmoplantar keratoderma ( PPK ). The most common manifestation of arsenic exposure in susceptible individuals is bilateral palmoplantar hyperkeratosis. We report a 67‐year‐old man with no known prior exposure to arsenic in the USA or family history of PPK who developed multiple squamous cell carcinoma in situ ( SCCIS ) and palmoplantar hyperkeratotic lesions beginning 23 years after service in V ietnam. The SCCIS were located on the trunk and extremities in both sun‐exposed and non‐sun‐exposed sites and his palmoplantar lesions were diagnosed concurrently with his SCCIS . He has continued to develop SCCIS since his first visit to our clinic 25 years ago.