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An increased risk of non‐ H odgkin lymphoma and chronic lymphocytic leukemia in US patients with M erkel cell carcinoma versus A ustralian patients: A clinical clue to a different mechanism of pathogenesis?
Author(s) -
Bloom Romi,
Amber Kyle T,
Nouri Keyvan
Publication year - 2016
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12325
Subject(s) - chronic lymphocytic leukemia , medicine , lymphoma , pathogenesis , leukemia , epidemiology , carcinoma , immunology , gastroenterology , cancer research , oncology
Abstract The US and Q ueensland populations both demonstrate an increased risk of secondary malignancies following the diagnosis of M erkel cell carcinoma (MCC). A recent Q ueensland study failed to demonstrate a significantly increased risk of developing non‐ H odgkin lymphoma ( NHL ) or chronic lymphocytic leukaemia ( CLL ) in these patients. In contrast, using the US Surveillance, Epidemiology, and End Results database, we demonstrate there is an increased risk in CLL and NHL following the diagnosis of MCC in the USA . We hypothesise that this difference may be a result of a differing pathogenesis.