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An A ustralian cohort of 210 patients with multiple invasive squamous cell carcinomas: risk factors and associated increased risk of melanoma and internal malignancies
Author(s) -
Banan Parastoo,
Marvi Salman K,
McMeniman Erin,
De'Ambrosis Brian
Publication year - 2016
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12278
Subject(s) - medicine , cohort , melanoma , oncology , cancer , skin cancer , cohort study , prostate cancer , cancer research
Background Patients with a history of non‐melanoma skin cancer ( NMSC ) have a 50% risk of developing subsequent NMSC . 13 Currently there are limited data on the association between multiple squamous cell carcinomas ( SCC ) and the risk of other cancers, including melanomas. Objective To assess the risk factors in a cohort of 210 A ustralians with a history of multiple invasive SCC , focusing on the association between multiple SCC and other cancers. Methods Data were collected from patients of a private practice in south‐east Q ueensland. Results A fair complexion and childhood sun exposure were found to be common in this cohort. Approximately half the patients who had their first SCC at or before the age of 30 years subsequently developed a melanoma. There was also an increased risk of internal cancer, prostate cancer being the commonest, followed by bowel and breast cancer. Conclusion Patients with a history of multiple invasive SCC should be aware of their increased risk of future NMSC and of melanomas. The results of thisstudy suggest such patients and their care providers should also consider an appropriate screening for internal malignancies.