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Dermoscopy, reflectance confocal microscopy and histopathology of a melanoma in situ from an individual homozygous for GSTP 1*105 V al/ MC 1 R *92 M et
Author(s) -
Banan Parastoo,
Lee Katie J,
McClenahan Phil,
Jagirdar Kasturee,
Sturm Richard A,
Soyer H Peter
Publication year - 2016
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/ajd.12250
Subject(s) - histopathology , melanoma , medicine , confocal microscopy , glutathione , pathology , in situ , microbiology and biotechnology , enzyme , cancer research , biology , chemistry , biochemistry , organic chemistry
Glutathione S ‐transferase 1 is an enzyme involved in the detoxification of reactive oxygen species, and the rs1695* V al polymorphism has been proposed as a melanoma‐associated variant with significant effect. We report a case of malignant melanoma in an individual homozygous for the rs1695* V al variant and discuss the non‐invasive and histopathological tools used in diagnosis.